Bone-M Bioscience

 

 

Bone pain, osteoporosis, gout, osteoarthritis, rheumatoid arthritis, has become the common degenerative diseases for our generation. Human has facing all this issue earlier, due to the changes of lifestyle and eating habit. Degenerative disease is a common problem in modern civilized society. In fact, this issue can be cured at the initial stage with health food or certain food supplement, however people tend to ignored it. At the end, they can only seek for physiology or surgery treatment. Please always remember, PREVENTION IS BETTER THAN CURE.

 

Bone-M^™ is a combination of nature and German biotechnology joint care health product. This product contains the Hydrolyzed collagen (which obtain through German Biotechnology), Mangosteen Skin Extract, Anti-inflammatory Probiotic, Inulin, Calcium lactate, Vitamin C, Mango Powder and Stevia Extract

 

Human bone density will increased gradually along the growing process. However, study shows the bone density start to deteriorate from age of 30. Each year, 15% of bone density will be regenerate in a healthy body. Therefore, irregular rate of calcium absorption can lead to bone density formation decreased and caused the osteoporosis. Collagen is an essential nutrient for body building, it composes 90% of cartilage protein, 80% of bones and muscles protein and 70% of human skin protein is actually collagen type protein as well. If lack of collagen type protein, we may face:

1.      Arthritis

 

2.      Osteoporosis

 

3.      Affect Joint Flexibility

 

4.      Blood vessels elasticity reduced

 

5.      Risk of CHD increased

 

6.      Slow down the wound healing process

 

7.      Causes skin aging

 

A number of studies have proved that 10 grams of hydrolyzed collagen intake for a period of 4-24 weeks can increase bone density.

 

Oesser et al (1999) investigate and prove that more than 95% of the oral administration of 14C-labeled hydrolyzed collagen will be absorbed. He also showed that within twelve hours after the intake is a critical moment because the hydrolyzed collagen will accumulate in the cartilage, and its emission level with the control group contrast more than twice (Figure 1). After oral administration of hydrolyzed collagen will be absorbed by the intestines, and then through the intestinal wall and reach the bone or cartilage tissue, in turn, stimulates the synthesis of cartilage or bone.

 

Bone-M^™ contains high amount of hydrolyzed collagen and it is enriched with mangosteen skin extract. The mangosteen skin is carefully monitored and strictly controlled from farm to tertiary processing; the quality of the skin extract is always excellent and consistent. The advanced biotechnology extraction process is used to obtain the skin extract; the whole extraction process is conducted by the extraction professionals.

 

In recent year, the mangosteen becomes widely popular around the world due to its high nutritional value. Up to now, thousand of research studies have been done on it from all over the world. Study has revealed mangosteen (Garcinia mangostana) contains high amount of xanthones, especially its skin. Base on the scientific report, xanthones are effective for anti-inflammation, anti-oxidant, anti-bacterial, anti-histamine, prevent diarrhea and cancer. There are two types of cyclooxygenase; which are COX-1 and COX-2. This two component have play an important role during the inflammation process; they mmanipulate the rate of prostaglandin synthase. γ-mangostin is the derivative from xanthones, it is being proved to effectively stop the activity of COX to reduce the inflammation rate.  

 

Other than anti-inflammation property, xanthones also possess the anti-oxidant properties. Table 1 show that mangosteen extract contain 77.8% of anti-oxidant activity.

 

Table 1: Free radical activity of Thai Medicinal Plant Extract.

 

	Plants	IC50  values	% superoxide radical
		(µg/ml)	inhibition ratio ± SD
	G.mangostana	6.13	77.80±1.28
	H. cordata	32.53	62.67±0.75
	E.odoratum	67.55	44.89±1.38
	S.alata	112.46	35.18±2.66
	B.lupulina	>150	10.74±0.86
	S.siamea	>150	67.60±1.47
	A.paniculata	>150	8.02±2.11

 

 

Bone-M^™ also enriched with anti-inflammatory probiotic- Lactobacillus reuteri. Studies have proved this probiotic able to increased the human *IL-10, and therefore can be more efficient in treating joint pain issue. However, not all the probiotic can trigger the *IL-10. Figure 3 has shown only Lactobacillus reuteri possess this function.

 

* Interleukin-10 (IL-10) is an anti-inflammatory cytokine.

 

Bone-M^™ is added with inulin as a prebiotic and calcium lactate as calcium source. The inulin can improve the digestive system and enhance the absorption of calcium and bone mineralization process. During the bone mass regeneration process, the calcium lactate is an important nutrient to speed

 

up the process. Bone-M^™ also contains the vitamin C and mango powder which responsible for collagen and as anti-oxidant source. Furthermore, the mango powder is rich in phytochemicals and an excellent source of carotenes, vitamin C and copper. The

 

sweetness for the Bone-M^™ is from stevia extract. It is kind of natural non-caloric sweetener, which will not trigger the glycemic index. Overall, Bone-M^™ is good source of collagen and suitable for diabetes people.